THE MODE OF ACTION OF DINITROPHENOL REVEALED BY MITOCHONDRIAL VOLUME CHANGES REQUIRING ROTENONE OR ANTIMYCIN OR DINITROPHENOL WITH SHOWDOMYCIN

The pivotal position of the mitochondrial thiol group exposed by dinitrophenol located by means of ATP energized mitochondrial volume changes requiring gramicidin, showdomycin, and dinitriphenol.

An appropriate concentration of DNP (2, 4-dinitrophenol) is capable of inhibiting the ATP energized mitochondrial volume change induced by gramicidin in the presence of the permeant ions potassium and L-malate. The further addition of the non-mercurial thiol reagent, showdomycin reinstates, an effect of gramicidin which is dependent upon potassium ion. Thus the strategically located nucleophili...

The action of 2,4-dinitrophenol on myosin.

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Neuroprotective actions of 2,4-dinitrophenol: Friend or foe?

2,4-dinitrophenol (DNP) has long been known to be toxic at high concentrations, an effect related to uncoupling of mitochondrial oxidative phosphorylation. Five years ago, however, we reported that low concentrations of DNP protect neurons against the toxicity of the amyloid-β peptide. Since then, a number of other studies have provided evidence of beneficial actions of DNP (at low concentratio...

The effects of 2,4-dinitrophenol on mitochondrial oxidations.

detection of volatile compounds of medicinal plants with some nano-sorbents using modified or new methodologies and investigation of antioxidant activity of their methanolic extracts

in this work, a novel and fast method for direct analysis of volatile compounds (davc) of medicinal plants has been developed by holding a filament from different parts of a plant in the gc injection port. the extraction and analysis of volatile components of a small amount of plant were carried out in one-step without any sample preparation. after optimization of temperature, extraction time a...